HCID 67861287, compound → HCID 178500829, compound

HRID 1085983Notes

Reaction equation

HRID 1085983 reaction equation
[C:1]([C:3](=[C:8]([C:10]1[CH:15]=[C:14]([F:16])[C:13]([F:17])=[CH:12][C:11]=1[Cl:18])[OH:9])[C:4]([O:6][CH3:7])=[O:5])#[N:2]>CO.[Ni]>[NH2:2][CH:1]=[C:3]([C:8](=[O:9])[C:10]1[CH:15]=[C:14]([F:16])[C:13]([F:17])=[CH:12][C:11]=1[Cl:18])[C:4]([O:6][CH3:7])=[O:5]

Participants

4

Reactant 1

HCID 67861287HCID 67861287, compound

Product 1

HCID 178500829HCID 178500829, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

1.0 g of the product from Example 2 was dissolved in methanol, 0.5 g of Raney nickel was added and hydrogenation was carried out under normal pressure at room temperature for four hours. The catalyst was separated off, the solution which remained was evaporated and the evaporation residue was recrystallized from i-propanol.

Workup

  1. customThe catalyst was separated off
  2. customthe solution which remained was evaporated
  3. customthe evaporation residue was recrystallized from i-propanol

Sources & evidence

ORD record
ord-ace8fa7e493f4bf69459bca87010b08a
Source dataset
uspto-grants-1991_04
Patent number
US05011971

Reaction notes

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