反应详情

To 50 ml of pyridine were added 0.0434 mole (9.77 g) of 2-benzyloxyacetophenone prepared in the first and second paragraphs in Referential Example 1 (Table 1, No. 1) and 4.35 g (0.0521 mole) of O-methylhydroxylamine hydrochloride. The mixture was stirred at room temperature for 2 hours and then at 100° C. for 1 hour. The reaction liquid was cooled down to room temperature, 300 ml of water was added thereto, and the oil layer was separated off. The aqueous layer was extracted with chloroform and the extract was combined with said oil layer, washed with water, dried and distilled under reduced pressure to obtain 10.77 g of 2-benzyloxyacetophenone O-methyloxime.

1. customprepared in the first and second paragraphs in Referential Example 1 (Table 1
2. waitat 100° C. for 1 hour
3. customThe reaction liquid
4. temperaturewas cooled down to room temperature
5. customthe oil layer was separated off
6. extractionThe aqueous layer was extracted with chloroform
7. washwashed with water
8. customdried
9. distillationdistilled under reduced pressure