反应详情

All the components (301 g of 46 percent aqueous KOH, 501 g of fluorobenzophenone, 800 mL of DMSO, and 269 g of fluorophenol), plus 5 mole percent BHT (25 g) were mixed together under a nitrogen atmosphere and distillation of water was carried out at a maximum temperature of 80° C. Reaction continued at 70° C. for a total of 12 hr. Purification by lights distillation gave an 87 percent yield of 4-(2-fluoro-phenoxy)benzophenone.

1. distillationdistillation of water
2. customwas carried out at a maximum temperature of 80° C
3. customReaction
4. customcontinued at 70° C. for a total of 12 hr
5. customPurification
6. distillationby lights distillation