p-Toluenesulfonic acid → Ethyl 2-ethyl-3,3-bis(4-fluorophenyl)propenoate

Participants

Reaction Steps

A mixture of ethyl 2-ethyl-3,3-bis(4-fluorophenyl)-3-hydroxypropionate (1.0 g, 3.0 mmol) and p-toluenesulfonic acid (0.2 g) in 100 mL toluene was heated at reflux for 1.25 hours. The mixture was cooled and washed with saturated sodium bicarbonate solution and water. The solution was dried with magnesium sulfate and concentrated in vacuo. The residue was crystallized from petroleum ether to give 0.85 g of the title compound; m.p. =57°-59° C.

Provenance & Evidence