反应详情

A mixture of ethyl 2-ethyl-3,3-bis(4-fluorophenyl)-3-hydroxypropionate (1.0 g, 3.0 mmol) and p-toluenesulfonic acid (0.2 g) in 100 mL toluene was heated at reflux for 1.25 hours. The mixture was cooled and washed with saturated sodium bicarbonate solution and water. The solution was dried with magnesium sulfate and concentrated in vacuo. The residue was crystallized from petroleum ether to give 0.85 g of the title compound; m.p. =57°-59° C.

1. temperaturewas heated
2. temperatureat reflux for 1.25 hours
3. temperatureThe mixture was cooled
4. washwashed with saturated sodium bicarbonate solution and water
5. dry with materialThe solution was dried with magnesium sulfate
6. concentrationconcentrated in vacuo
7. customThe residue was crystallized from petroleum ether