2-Ethyl-3,3-bis(4-fluorophenyl)-2-propenol → 2-Ethyl-3,3-bis(4-fluorophenyl)-2-propenal

HRID 1086094Notes

Reaction equation

HRID 1086094 reaction equation
[CH2:1]([C:3](=[C:6]([C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[C:7]1[CH:12]=[CH:11][C:10]([F:13])=[CH:9][CH:8]=1)[CH2:4][OH:5])[CH3:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH2:1]([C:3](=[C:6]([C:7]1[CH:8]=[CH:9][C:10]([F:13])=[CH:11][CH:12]=1)[C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[CH:4]=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 151330492-Ethyl-3,3-bis(4-fluorophenyl)-2-propenol

Product 1

HCID 151330552-Ethyl-3,3-bis(4-fluorophenyl)-2-propenalYield 99.4%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

Activated manganese dioxide (49 g) was added to a solution of 2-ethyl-3,3-bis(4-fluorophenyl)-2-propenol (7 g, 25.5 mmol) in 100 mL of methylene chloride and the mixture stirred for 18 hours. The insolubles were removed and the solution concentrated in vacuo to give 6.9 g of the title compound as an oil. MS(CI): m/e =272 for M+ of C17H14F2O.

Workup

  1. customThe insolubles were removed
  2. concentrationthe solution concentrated in vacuo

Sources & evidence

ORD record
ord-81efca05a4e642eab12275043086807e
Source dataset
uspto-grants-1991_04
Patent number
US05011947

Reaction notes

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