HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → Z-Pro-Val-OtBu
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Benzyloxycarbonyl-L-proline | HCID 101987 | — |
| Reactant | tert-butyl (2S)-2-amino-3-methylbutanoate hydrochloride | HCID 12490702 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Z-Pro-Val-OtBu | HCID 12286264 | — |
Reaction Steps
1.3 ml of N-ethylmorpholine and 2.2 g of DCC are added, at 0° C., to a solution of 2.49 g of Z-Pro-OH, 2.1 g of H-Val-OtBu.HCl and 1.35 g of HOBt in 20 ml of dimethylformamide. The subsequent procedure is as in Example 8a. The residue is triturated with petroleum ether, filtered off with suction and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05011825 |
| Source dataset | uspto-grants-1991_04 |
| ORD ID | ord-318aacdf3a8848eca16a0bc42725c105 |
| Source note | uspto-grants-1991_04 |