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HRID1086116

反应详情

EQUATION

反应方程式

HRID 1086116 的结构方程式

REACTANTS

反应物

1
结构：CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1)C(=O)OC(C)(C)C
HCID12286264

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1)C(=O)O
HCID73512

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=C(O)C(F)(F)F
溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

2.63 g of Z-Pro-Val-OtBu are dissolved in 20 ml of 90% trifluoroacetic acid. The mixture is left to stand at room temperature for one hour, and is concentrated. The residue is triturated with water. The precipitate is filtered off with suction and dried over P2O5. For further purification, the product is chromatographed on silica gel in CH2Cl2 /CH30H/petroleum ether/acetic acid/water 18:1:2:0.1:0.1.

WORKUP

后处理

  1. waitThe mixture is left
  2. concentrationis concentrated
  3. customThe residue is triturated with water
  4. filtrationThe precipitate is filtered off with suction
  5. dry with materialdried over P2O5
  6. customFor further purification
  7. customthe product is chromatographed on silica gel in CH2Cl2 /CH30H/petroleum ether/acetic acid/water 18:1:2:0.1:0.1