HCID 131716870, compound → HCID 131716869, compound

HRID 1086123Notes

Reaction equation

HRID 1086123 reaction equation
[NH:1]([C:36]([O:38][CH2:39][CH:40]1[C:52]2[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=2)[C:46]2[C:41]1=[CH:42][CH:43]=[CH:44][CH:45]=2)=[O:37])[C@H:2]([C:18]([NH:20][C@H:21]([C:29]([O:31]C(C)(C)C)=[O:30])[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:19])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9]>FC(F)(F)C(O)=O>[NH:1]([C:36]([O:38][CH2:39][CH:40]1[C:52]2[C:47](=[CH:48][CH:49]=[CH:50][CH:51]=2)[C:46]2[C:41]1=[CH:42][CH:43]=[CH:44][CH:45]=2)=[O:37])[C@H:2]([C:18]([NH:20][C@H:21]([C:29]([OH:31])=[O:30])[CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)=[O:19])[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]([O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:9]

Participants

3

Reactant 1

HCID 131716870HCID 131716870, compound

Product 1

HCID 131716869HCID 131716869, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2.95 g of Fmoc-Lys(Z)-Phe-OtBu are dissolved in 30 ml of 90% strength aqueous trifluoroacetic acid. The solution is left to stand at room temperature for one hour, and is concentrated in vacuo. The residue is triturated with diethyl ether and filtered off with suction.

Workup

  1. waitThe solution is left
  2. concentrationis concentrated in vacuo
  3. customThe residue is triturated with diethyl ether
  4. filtrationfiltered off with suction

Sources & evidence

ORD record
ord-6f009bd556d44502b1313fb24f6be7ca
Source dataset
uspto-grants-1991_04
Patent number
US05011825

Reaction notes

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