HRID1086125

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)OC(C)(C)C

HCID178455928

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O

HCID178455927

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

15.8 g of Fmoc-Arg-Ile-OtBu are dissolved in 150 ml of 90% strength aqueous trifluoroacetic acid. The solution is left to stand at room temperature for 1 hour, and is concentrated. The residue is triturated twice with diethyl ether, the ether being decanted off each time. Water is added to the residue, and the pH is adjusted to with saturated NaHCO3 solution. The precipitate is filtered off with suction and dried.

WORKUP

后处理

waitThe solution is left
concentrationis concentrated
customThe residue is triturated twice with diethyl ether
customthe ether being decanted off each time
additionWater is added to the residue
filtrationThe precipitate is filtered off with suction
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7cc252e9a0024683826e317a26012343
来源数据集: uspto-grants-1991_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05011825
来源说明: uspto-grants-1991_04

反应 SMILES

[NH:1]([C:25]([O:27][CH2:28][CH:29]1[C:41]2[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=2)[C:35]2[C:30]1=[CH:31][CH:32]=[CH:33][CH:34]=2)=[O:26])[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20]C(C)(C)C)=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:9])[NH2:8]>FC(F)(F)C(O)=O>[NH:1]([C:25]([O:27][CH2:28][CH:29]1[C:30]2[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:36]2[C:41]1=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:26])[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([OH:20])=[O:19])[C@H:14]([CH2:16][CH3:17])[CH3:15])=[O:11])[CH2:3][CH2:4][CH2:5][NH:6][C:7](=[NH:8])[NH2:9]