HCID 19826884, compound → HCID 19826893, compound

HRID 1086156Notes

Reaction equation

HRID 1086156 reaction equation
[Cl:1][C:2]1[S:3][C:4](Cl)=[C:5]2[CH:11]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:10][N:9]([CH3:18])[CH2:8][CH2:7][C:6]=12>[Pd].C(O)(=O)C>[Cl:1][C:2]1[S:3][CH:4]=[C:5]2[CH:11]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:10][N:9]([CH3:18])[CH2:8][CH2:7][C:6]=12

Participants

4

Reactant 1

HCID 19826884HCID 19826884, compound

Product 1

HCID 19826893HCID 19826893, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A mixture of 1,3-dichloro-6-methyl-4-phenyl-5,6,7,8-tetrahydro-4H-thieno[3,4-d]azepine (73 mg) and 10% palladium on carbon (20 mg) in acetic acid (2 ml) was hydrogenated for 24 hours at 60 p.s.i. The mixture was filtered and the filtrate evaporated to a yellow oil. Chromatography on silica (1% methanol-ammonia in dichloromethane) gave the title product as an oil.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated to a yellow oil

Sources & evidence

ORD record
ord-51d10632cd60406fbf9a962fcbb94d05
Source dataset
uspto-grants-1991_07
Patent number
US05028602

Reaction notes

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