Methylamine → Imidazo(1,2-a)pyrazin-8-amine, 3-bromo-N-methyl-

HRID 1086168Notes

Reaction equation

HRID 1086168 reaction equation
[Br:1][C:2]1[N:6]2[C:7](Br)=[CH:8][N:9]=[CH:10][C:5]2=[N:4][CH:3]=1.[CH3:12][NH2:13]>>[Br:1][C:2]1[N:6]2[CH:7]=[CH:8][N:9]=[C:10]([NH:13][CH3:12])[C:5]2=[N:4][CH:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 142075923,5-Dibromoimidazo[1,2-a]pyrazine

Product 1

HCID 3088360Imidazo(1,2-a)pyrazin-8-amine, 3-bromo-N-methyl-Yield 40%

Procedure

A mixture of 1 g (3,6 mmol) of 3,5-dibromoimidazo[1,2-a]pyrazine in 9 ml of a 40% strength aqueous methylamine solution is maintained with stirring for 12 hours. After evaporation under reduced pressure and chromatography on a silica column eluted with ether, 0.33 g (Yld=40%) of 3-bromo-8-methylaminoimidazo[1,2-a]pyrazine (m.p. 139° C.) is obtained.

Workup

  1. temperatureis maintained
  2. customAfter evaporation under reduced pressure and chromatography on a silica column
  3. washeluted with ether

Sources & evidence

ORD record
ord-6407c8b136074021ba1d59c3f97828a8
Source dataset
uspto-grants-1991_07
Patent number
US05028605

Reaction notes

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