Ethylamine → HCID 14207595, compound

HRID 1086173Notes

Reaction equation

HRID 1086173 reaction equation
[Cl:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[C:5](Cl)=[N:4][CH:3]=1.[CH2:12]([NH2:14])[CH3:13]>>[CH2:12]([NH:14][C:5]1[C:6]2[N:7]([CH:8]=[CH:9][N:10]=2)[C:2]([Cl:1])=[CH:3][N:4]=1)[CH3:13]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 14207621HCID 14207621, compound

Product 1

HCID 14207595HCID 14207595, compound

Procedure

A solution of 1.5 g (9.8 mmol) of 5,8-dichloroimidazo[ 1,2-a]pyrazine in 25 ml of a 40% strength aqueous ethylamine solution is maintained with stirring for 12 hours. After concentration under reduced pressure and chromatography on a silica column (eluant=ether), 5-chloro-8-ethylaminoimidazo[1,2-a]pyrazine (m.p. 94° C.), is obtained.

Workup

  1. concentrationAfter concentration under reduced pressure and chromatography on a silica column (eluant=ether), 5-chloro-8-ethylaminoimidazo[1,2-a]pyrazine (m.p. 94° C.)
  2. customis obtained

Sources & evidence

ORD record
ord-49779614ad9446ab9106858460f94bd4
Source dataset
uspto-grants-1991_07
Patent number
US05028605

Reaction notes

Loading…