Sodium Carbonate → 3,6,8-Tribromoimidazo[1,2-a]pyrazine

HRID 1086174Notes

Reaction equation

HRID 1086174 reaction equation
[Br:1][C:2]1[N:3]=[C:4]([Br:11])[C:5]2[N:6]([CH:8]=[CH:9][N:10]=2)[CH:7]=1.[Br:12]N1C(=O)CCC1=O.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:12][C:8]1[N:6]2[CH:7]=[C:2]([Br:1])[N:3]=[C:4]([Br:11])[C:5]2=[N:10][CH:9]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 67184N-bromobutanimideHCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

Product 1

HCID 142076223,6,8-Tribromoimidazo[1,2-a]pyrazine

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 0.8 g (2.9 mmol) of 6,8-dibromoimidazo[1,2-a]pyrazine and 1.2 g of N-bromosuccinimide in 40 ml of chloroform is brought to reflux for two hours. After being cooled, the organic solution is treated with aqueous Na2CO3 solution. The chloroform phase is collected and then evaporated. 1 g -(Yld=97%) of 3,6,8-tribromoimidazo[1,2-a]pyrazine (m.p. 161° C.) is obtained.

Workup

  1. temperatureto reflux for two hours
  2. temperatureAfter being cooled
  3. customThe chloroform phase is collected
  4. customevaporated

Sources & evidence

ORD record
ord-6ae912ba9eb44bfab634123c48a48334
Source dataset
uspto-grants-1991_07
Patent number
US05028605

Reaction notes

Loading…