HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → 3,6,8-Tribromoimidazo[1,2-a]pyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 6,8-Dibromoimidazo[1,2-a]pyrazine | HCID 15025843 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3,6,8-Tribromoimidazo[1,2-a]pyrazine | HCID 14207622 | — |
Reaction Steps
A solution of 0.8 g (2.9 mmol) of 6,8-dibromoimidazo[1,2-a]pyrazine and 1.2 g of N-bromosuccinimide in 40 ml of chloroform is brought to reflux for two hours. After being cooled, the organic solution is treated with aqueous Na2CO3 solution. The chloroform phase is collected and then evaporated. 1 g -(Yld=97%) of 3,6,8-tribromoimidazo[1,2-a]pyrazine (m.p. 161° C.) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05028605 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-6ae912ba9eb44bfab634123c48a48334 |
| Source note | uspto-grants-1991_07 |