反应详情

Into a 4 ml of tetrahydrofuran were dissolved 0.82 g of 1-(2-indanylacetyl)-L-proline and 0.35 g of N-hydroxysuccinimide. To the solution was dropwise added a solution of 0.74 g of DCC in 2 ml of tetrahydrofuran at room temperature with stirring. After stirring for a further 17 hours at the same temperature, insoluble components were removed by filtration. From the filtrate the solvent was evaporated under reduced pressure. The oily residue thus obtained was washed with n-hexane, dissolved in 5 ml of benzene, and treated with activated carbon. Benzene was evaporated under reduced pressure to produce 0.72 g of 1-(2-indanylacetyl)-L-prolyloxysuccinimide as coloress amorphous solid.

1. stirringAfter stirring for a further 17 hours at the same temperature, insoluble components
2. customwere removed by filtration
3. customFrom the filtrate the solvent was evaporated under reduced pressure
4. customThe oily residue thus obtained
5. washwas washed with n-hexane
6. dissolutiondissolved in 5 ml of benzene
7. additiontreated with activated carbon
8. customBenzene was evaporated under reduced pressure