Thiazolidine → HCID 70048912, compound

HRID 1086279Notes

Reaction equation

HRID 1086279 reaction equation
[CH:1]1([CH2:10][C:11]([N:13]2[CH2:20][CH2:19][CH2:18][C@H:14]2[C:15]([OH:17])=O)=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1.C1(CC(C2SCN[C@@H]2C(O)=O)=O)C2C(=CC=CC=2)CC1.S1CCNC1>>[CH:1]1([CH2:10][C:11]([N:13]2[CH2:20][CH2:19][CH2:18][C@H:14]2[C:15]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[O:17])=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

Participants

5

Reactant 4

HCID 10444ThiazolidineHCID 31268PyrrolidineHCID 572056241-(2-indenylacetyl)-L-prolineHCID 1317169183-(2-indanylacetyl)-L-thioproline

Product 1

HCID 70048912HCID 70048912, compoundYield 62%

Procedure

A pale yellow amorphous solid of 1-[1-(2-indenyl-acetyl)-L-prolyl]pyrrolidine was prepared in the same manner as in Example 1, except that 1-(2-indenylacetyl)-L-proline and pyrrolidine were used instead of 3-(2-indanylacetyl)-L-thioproline and thiazolidine, respectively (yield: 62%).

Sources & evidence

ORD record
ord-38fb95f09150416b8b30aabf59204a2c
Source dataset
uspto-grants-1991_07
Patent number
US05028604

Reaction notes

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