Thiazolidine → HCID 15021244, compound

HRID 1086282Notes

Reaction equation

C1C2C(=CC=CC=2)CCC1C[C:12]([N:14]1[CH2:21][CH2:20][CH2:19][C@H:15]1C(O)=O)=[O:13].[NH:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1.[CH:27]1([CH2:36][C:37](C2SCN[C@@H]2C(O)=O)=[O:38])[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28]1.S1CCN[CH2:48]1>>[CH2:48]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:29][CH2:28][CH:27]1[CH2:36][C:37]([N:22]1[CH2:26][CH2:25][CH2:24][C@H:23]1[C:12]([N:14]1[CH2:21][CH2:20][CH2:19][CH2:15]1)=[O:13])=[O:38]

Participants

Reactant 4

HCID 10444Thiazolidine

HCID 31268Pyrrolidine

HCID 15021263HCID 15021263, compound

HCID 1317169183-(2-indanylacetyl)-L-thioproline

Product 1

HCID 15021244HCID 15021244, compoundYield 46%

Procedure

Colorless crystals of 1-[1-(1,2,3,4-tetrahydronaphthalen-2-ylacetyl)-L-prolyl]pyrrolidine were prepared in the same manner as in Example 1, except that 1-(1,2,3,4-tetrahydronaphthalen-2-ylacetyl)-L-proline and pyrrolidine were used instead of 3-(2-indanylacetyl]-L-thioproline and thiazolidine, respectively (yield: 46%).

Sources & evidence

ORD record: ord-c756f9cb305e4f68a49ff6f2b3d46d95
Source dataset: uspto-grants-1991_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05028604

Reaction notes

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