Thiazolidine → HCID 131716929, compound

HRID 1086285Notes

Reaction equation

[CH:1]1([CH2:10][C:11]([CH:13]2[S:17][CH2:16][NH:15][C@H:14]2[C:18]([OH:20])=O)=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1.C1(CC(C2SCN[C@@H]2C(O)=O)=O)C2C(=CC=CC=2)CC1.S1CCNC1>>[CH:1]1([CH2:10][C:11]([CH:13]2[S:17][CH2:16][NH:15][C@H:14]2[C:18]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)=[O:20])=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

Reactant 4

HCID 10444Thiazolidine

HCID 31268Pyrrolidine

HCID 1317169183-(2-indanylacetyl)-L-thioproline

HCID 131716930HCID 131716930, compound

Product 1

HCID 131716929HCID 131716929, compoundYield 44%

Procedure

Colorless crystals of 1-[3-(2-indanylacetyl)-D-thioprolyl]pyrrolidine were prepared in the same manner as in Example 1, except that 3-(2-indanylacetyl)-D-thioproline prepared in Reference Example 26 and pyrrolidine were used instead of 3-(2-indanylacetyl)-L-thioproline and thiazolidine, respectively (yield: 44%).

Sources & evidence

ORD record: ord-c2b4bbfd77504d79b85c8033b0bd047d
Source dataset: uspto-grants-1991_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05028604

Reaction notes

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