Thiazolidine → HCID 54150658, compound

HRID 1086286Notes

Reaction equation

HRID 1086286 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([CH2:13][C:14]([N:16]1[CH2:23][CH2:22][CH2:21][C@H:17]1[C:18](O)=[O:19])=[O:15])[CH2:7][CH2:6]2.[NH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1.C1(CC(C2SCN[C@@H]2C(O)=O)=O)C2C(=CC=CC=2)CC1.S1CCNC1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][CH:8]([CH2:13][C:14]([N:16]1[CH2:23][CH2:22][CH2:21][C@H:17]1[C:18]([N:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:19])=[O:15])[CH2:7][CH2:6]2

Participants

5

Reactant 4

HCID 10444ThiazolidineHCID 31268PyrrolidineHCID 15021269HCID 15021269, compoundHCID 1317169183-(2-indanylacetyl)-L-thioproline

Product 1

HCID 54150658HCID 54150658, compoundYield 24%

Procedure

A colorless oil of 1-[1-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylacetyl)-L-prolyl]pyrrolidine was prepared in the same manner as in Example 1, except that 1-(6-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylacetyl)-L-proline prepared in Reference Example 21 and pyrrolidine were used instead of 3-(2-indanylacetyl)-L-thioproline and thiazolidine, respectively (yield: 24%).

Sources & evidence

ORD record
ord-e6ad7e23aeab4b7c99bd13edbfb1ab79
Source dataset
uspto-grants-1991_07
Patent number
US05028604

Reaction notes

Loading…