Thiazolidine → HCID 131716933, compound

HRID 1086288Notes

Reaction equation

[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([CH2:13][C:14]([CH:16]1[S:20][CH2:19][NH:18][C@@H:17]1[C:21](O)=[O:22])=[O:15])[CH2:7]2.[NH:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1.C1(CC(C2SCN[C@@H]2C(O)=O)=O)C2C(=CC=CC=2)CC1.S1CCNC1>>[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([CH2:13][C:14]([CH:16]1[S:20][CH2:19][NH:18][C@@H:17]1[C:21]([N:24]1[CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:22])=[O:15])[CH2:7]2

Participants

Reactant 4

HCID 10444Thiazolidine

HCID 31268Pyrrolidine

HCID 1317169183-(2-indanylacetyl)-L-thioproline

HCID 131716934HCID 131716934, compound

Product 1

HCID 131716933HCID 131716933, compoundYield 60%

Procedure

A colorless oil of 1-[3-(5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-2-ylacetyl)-L-thioprolyl]pyrrolidine was prepared in the same manner as in Example 1, except that 3-(5,7-dimethyl-1,2,3,4-tetrahydronaphthalen-2-ylacetyl)-L-thioproline prepared in Reference Example 25 and pyrrolidine were used instead of 3-(2-indanylacetyl)-L-thioproline and thiazolidine, respectively (yield: 60%).

Sources & evidence

ORD record: ord-fb252b6a0586430883df39884dfcc257
Source dataset: uspto-grants-1991_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05028604

Reaction notes

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