Thiazolidine → HCID 131716938, compound

HRID 1086296Notes

Reaction equation

[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@H:2]1[CH2:11][C:12]([CH:14]1[S:18][CH2:17][NH:16][C@@H:15]1[C:19]([OH:21])=O)=[O:13].[NH:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1.C1(CC(C2SCN[C@@H]2C(O)=O)=O)C2C(=CC=CC=2)CC1.S1CCNC1>>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C@H:2]1[CH2:11][C:12]([CH:14]1[S:18][CH2:17][NH:16][C@@H:15]1[C:19]([N:22]1[CH2:26][CH2:25][CH2:24][CH2:23]1)=[O:21])=[O:13]

Participants

Reactant 4

HCID 10444Thiazolidine

HCID 31268Pyrrolidine

HCID 1317169183-(2-indanylacetyl)-L-thioproline

HCID 131716939HCID 131716939, compound

Product 1

HCID 131716938HCID 131716938, compoundYield 31%

Procedure

Colorless crystals of 1-{3-[(R)-(+)-1,2,3,4-tetrahydronaphthalen-2-ylacetyl]-L-thioprolyl}pyrrolidine were prepared in the same manner as in Example 1, except that 3-[(R)-(+)-1,2,3,4-tetrahydronaphthalen-2-ylacetyl]-L-thioproline prepared in Reference Example 34 and pyrrolidine were used instead of 3-(2-indanylacetyl)-L-thioproline and thiazolidine, respectively (yield: 31%).

Sources & evidence

ORD record: ord-64203987deca4136abb11607f9030b1d
Source dataset: uspto-grants-1991_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05028604

Reaction notes

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