Hydrazine hydrate (1:1) → 5-amino-3-[N-(2-mercaptoethyl)benzylamino]-1,2,4-triazole

HRID 1086302Notes

Reaction equation

HRID 1086302 reaction equation
[CH2:1]([N:8]1[CH2:12][CH2:11][S:10][C:9]1=[N:13][C:14]#[N:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:17][NH2:18]>>[NH2:15][C:14]1[NH:18][N:17]=[C:9]([N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:12][CH2:11][SH:10])[N:13]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 14306192(3-Benzyl-1,3-thiazolidin-2-ylidene)cyanamide

Product 1

HCID 542050265-amino-3-[N-(2-mercaptoethyl)benzylamino]-1,2,4-triazole

Procedure

A mixture of 1.84 g of 3-benzyl-2-cyanoiminothiazolidine and 10 ml of hydrazine monohydrate was heated at reflux under an algon atmosphere for an hour. After the reaction, the solvent was evaporated under reduced pressure, and the residue was recrystallized from ethanol to give 2 g of 5-amino-3-[N-(2-mercaptoethyl)benzylamino]-1,2,4-triazole (Compound 1).

Workup

  1. temperaturewas heated
  2. temperatureat reflux under an algon atmosphere for an hour
  3. customAfter the reaction
  4. customthe solvent was evaporated under reduced pressure
  5. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-6b3bed50780b496fbf37f604e8a3a2b7
Source dataset
uspto-grants-1991_07
Patent number
US05028716

Reaction notes

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