Benzyl Chloride → Phenylpyruvic acid

HRID 1086358Notes

Reaction equation

HRID 1086358 reaction equation
[O:1]=[C:2]([CH:6]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)CC1C=CC=CC=1)[C:3]([OH:5])=[O:4].C(Cl)C1C=CC=CC=1>O1CCOCC1>[C:14]1([CH2:6][C:2](=[O:1])[C:3]([OH:5])=[O:4])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 7503Benzyl ChlorideHCID 10753428HCID 10753428, compound

Product 1

HCID 997Phenylpyruvic acidYield 63%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

By the same operation as in Example 61 except that 6 ml of 1,4-dioxane was used as the solvent, 2-oxo-3,4-diphenylbutanoic acid formed in a yield of 63 % by the reaction of 0.49 g (3 mmoles) of phenylpyruvic acid with 0.5 ml of benzyl chloride, as determined by NMR spectral analysis.

Sources & evidence

ORD record
ord-6d41415247e646ee94947bad41fddfa4
Source dataset
uspto-grants-1991_07
Patent number
US05028738

Reaction notes

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