Water → HCID 54041436, compound

HRID 1086370Notes

Reaction equation

HRID 1086370 reaction equation
CN(C=[O:5])C.[CH3:6][S:7][C:8]1[C:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=[C:10]([Si](C)(C)C)[C:9]=1[C:24]1OCC(C)(C)N=1.[F-].[CH2:32]([N+:36]([CH2:45]CCC)(CCCC)CCCC)[CH2:33]CC.[OH2:49]>>[CH3:6][S:7][C:8]1[C:13]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH3:19])=[CH:12][CH:11]=[CH:10][C:9]=1[CH:24]=[CH:33][C:32]([N:36]([OH:5])[CH3:45])=[O:49]

Participants

5

Reactant 4

HCID 962Water2×HCID 6228DimethylformamideHCID 2724141Tetrabutylammonium FluorideHCID 19827193HCID 19827193, compound

Product 1

HCID 54041436HCID 54041436, compound

Procedure

To 100 ml of DMF with 10 ml of water is added (2-methylthio-3-n-hexyl-6-trimethylsilylphenyl)-4,4-dimethyloxazoline and 20 g of tetrabutylammonium fluoride and refluxed overnight. The reaction mixture is cooled and then poured into water and extracted with diethyl ether. The extracts are washed with water and then brine, dried over MgSO4, and concentrated to afford the subtitle compound.

Workup

  1. temperaturerefluxed overnight
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with diethyl ether
  4. washThe extracts are washed with water
  5. dry with materialbrine, dried over MgSO4
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-cd51c3c17740467eafe7faff94f6ad1c
Source dataset
uspto-grants-1991_07
Patent number
US05028629

Reaction notes

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