反应详情

A solution of 74.0 g (0.489 mol) of N-(2-hydroxyethyl)-N-methylaniline in 100 mL of pyridine was treated dropwise with 55 g (0.54 mol) of acetic anhydride. The resulting mixture was heated at reflux for 10 hr, then cooled and poured onto 500 g of ice. The mixture was extracted three times with dichloromethane (3×100 mL), the combined extracts were dried using magnesium sulfate (MgSO4) and the solvent was evaporated. The residue was distilled at reduced pressure, producing 84.2 g of a slightly yellow oil, b.p. 107°-116° C. (0.4 mm).

1. temperatureThe resulting mixture was heated
2. temperatureat reflux for 10 hr
3. temperaturecooled
4. extractionThe mixture was extracted three times with dichloromethane (3×100 mL)
5. customthe combined extracts were dried
6. customthe solvent was evaporated
7. distillationThe residue was distilled at reduced pressure
8. customproducing 84.2 g of a slightly yellow oil, b.p. 107°-116° C. (0.4 mm)