Water → HCID 14773690, compound

HRID 1086412Notes

Reaction equation

HRID 1086412 reaction equation
C([C:5]1[C:6]([CH2:18][O:19][SiH](C)C)=[C:7]([N:11]2[CH2:14][C:13]([F:16])([F:15])[C:12]2=[O:17])[CH:8]=[CH:9][CH:10]=1)(C)(C)C.O.C([O-])(O)=O.[Na+]>C(#N)C>[OH:19][CH2:18][C:6]1[CH:5]=[CH:10][CH:9]=[CH:8][C:7]=1[N:11]1[CH2:14][C:13]([F:15])([F:16])[C:12]1=[O:17]

Participants

5

Reactant 3

HCID 962WaterHCID 516892Sodium BicarbonateHCID 137329063HCID 137329063, compound

Product 1

HCID 14773690HCID 14773690, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

0.19 mmole of compound 3a is dissolved in 1 ml of acetonitrile and this solution is added dropwise to a 40% H2O/HF mixture corresponding to 3 eq. Stirring is maintained for 5 min. at ambient temperature, followed by the neutralization of the excess HF by a 5% aqueous NaHCO3 solution.

Sources & evidence

ORD record
ord-067cad79b9e044d491cd04790ff32282
Source dataset
uspto-grants-1991_07
Patent number
US05030628

Reaction notes

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