Bromotrimethylsilane → HCID 10039097, compound

HRID 1086415Notes

Reaction equation

HRID 1086415 reaction equation
O[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:12][C:11]([F:14])([F:13])[C:10]1=[O:15].C[Si]([Br:20])(C)C>>[Br:20][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:12][C:11]([F:14])([F:13])[C:10]1=[O:15]

Participants

3

Reactant 2

HCID 76113BromotrimethylsilaneHCID 14773690HCID 14773690, compound

Product 1

HCID 10039097HCID 10039097, compoundYield 25%

Procedure

60 mg (0.28 mmole) of compound 4a are treated with 4 equivalents (0.15 ml) of trimethylsilylbromide at ambient temperature for 35 min. The compound obtained is purified by silica gel plate chromatography using an ether:pentane mixture (1:6). This gives 16 mg of compound 5d corresponding to a 25% yield.

Workup

  1. customThe compound obtained
  2. customis purified by silica gel plate chromatography

Sources & evidence

ORD record
ord-211de8de5dc0442f80c68016e1b092c4
Source dataset
uspto-grants-1991_07
Patent number
US05030628

Reaction notes

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