反应详情

N-methyl-N-[2-(2-pyridinyl)ethyl]-2-propenamide (0.95 g, 0.005 mole) was dissolved in methanol (200 ml) containing 2,6-bis(1,1-dimethylethyl)-4-mercaptophenol (1.19 g, 0.005 mole). After addition of triethylamine (0.5 ml), the solution was stirred at room temperature overnight. The solvent was removed by a nitrogen stream to give a residue which was purified by chromatography on silica to give the title compound, m.p. ca. 82°-84° C. Anal. calcd. for C25H36N2O2S(428.62): Calc.: C, 70.05; H, 8.47; N, 6.54; S, 7.47. Found: C, 70.45; H, 8.50; N, 6.60; S, 7.55.

1. customThe solvent was removed by a nitrogen stream
2. customto give a residue which
3. customwas purified by chromatography on silica