4-Chlorobenzenesulfonyl chloride → 2-[N-[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetyl-N-methylamino]-acetic acid

HRID 1086520Notes

Reaction equation

HRID 1086520 reaction equation
Cl.[NH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:12][C:13]([O:15]C)=O)[CH:9]=2)[CH2:4]1.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1.Cl.[CH3:29][NH:30][CH2:31][C:32]([O:34]C)=[O:33]>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([NH:2][CH:3]2[CH2:11][C:10]3[C:5](=[CH:6][CH:7]=[C:8]([CH2:12][C:13]([N:30]([CH2:31][C:32]([OH:34])=[O:33])[CH3:29])=[O:15])[CH:9]=3)[CH2:4]2)(=[O:26])=[O:25])=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 83544Glycine, N-methyl-, methyl ester, hydrochloride (1:1)HCID 23359670Methyl (2-aminoindan-5-yl)acetate hydrochloride

Product 1

HCID 148839822-[N-[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetyl-N-methylamino]-acetic acid

Procedure

In the same manner as described in Examples 24 and 33, methyl (2-aminoindan-5-yl)acetate hydrochloride, 4-chlorophenylsulfonyl chloride and methyl N-methyl-glycinate hydrochloride are treated to give 2-[N-[2-[(4-chlorophenyl)sulfonylamino]indan-5-yl]acetyl-N-methylamino]-acetic acid

Workup

  1. additionare treated

Sources & evidence

ORD record
ord-7bf9697d0616420c85c3b2af21eb3d1c
Source dataset
uspto-grants-1991_07
Patent number
US05030652

Reaction notes

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