反应详情

A mixture of methyl 3-(6-nitro-2,3-dihydrobenz-1,4-oxazin-4-ylmethyl)benzoate (0.65 g.) and palladium-on-carbon (10% w/w, 0.025 g.) in ethyl acetate (40 ml.) was hydrogenated at an initial pressure of 2.9 bar. The catalyst was removed by filtration through diatomaceous earth, washing the filter cake with ethyl acetate, and the filtrate was evaporated to give methyl 3-(6-amino-2,3-dihydrobenz-1,4-oxazin-4-ylmethyl)benzoate (X) (0.3 g., 51%) as a gum: partial NMR (80 MHz, CDCl3) 3.3(m,2H, N.CH2CH2O); 3.9(s,3H, OMe); 4.15(m,2H, N.CH2.CH2.O); 4.5(s,2H, NCH2Ar).

1. customThe catalyst was removed by filtration through diatomaceous earth
2. washwashing the filter cake with ethyl acetate
3. customthe filtrate was evaporated