反应详情

A mixture of 40 g of potassium carbonate, 0.380 g of couronne 18 crown 6 ether catalyst and 39.9 g of chloromethylpropene was added to a solution of 30 g of ethyl formamidomalonate in 300 ml of acetonitrile and the mixture was refluxed for 3 hours and was filtered. The mixture was evaporated to dryness, cooled to 0° to -5° C. and was taken up in 10 ml of isopropyl ether. The mixture was filtered and the product was washed with isopropyl ether and dried under reduced pressure to obtain 25.2 g of the expected melting at ≈72° C.

1. temperaturethe mixture was refluxed for 3 hours
2. filtrationwas filtered
3. customThe mixture was evaporated to dryness
4. temperaturecooled to 0° to -5° C.
5. filtrationThe mixture was filtered
6. washthe product was washed with isopropyl ether
7. customdried under reduced pressure
8. customto obtain 25.2 g of the expected melting at ≈72° C.