Sodium Hydroxide → HCID 53656916, compound

HRID 1086592Notes

Reaction equation

HRID 1086592 reaction equation
[NH2:1][CH:2]([C:10]([OH:12])=[O:11])[CH2:3][CH:4]=[CH:5][CH2:6][C:7]([OH:9])=[O:8].[OH-].[Na+]>C(O)C>[NH2:1][CH:2]([C:10]([OH:12])=[O:11])[CH2:3][CH2:4][CH:5]=[CH:6][C:7]([OH:9])=[O:8]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 53727145HCID 53727145, compound

Product 1

HCID 53656916HCID 53656916, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g of the product of Step D were dissolved in 10 ml of ethanol and 5.1 ml of a 2N solution of sodium hydroxide were added. The mixture was stirred for 16 hours at ambient temperature and the mixture was evaporated to dryness under reduced pressure. The product obtained was neutralized with resin Dowex 50 W×8 and the fractions containing the desired product were evaporated to dryness. A product was obtained which was lyophilized in 150 ml of filtered, double distilled water to obtain 660 mg of the expected product with a Rf=0.5 in a BuOH--AcOH--H2O mixture (4-2-2).

Workup

  1. customthe mixture was evaporated to dryness under reduced pressure
  2. customThe product obtained

Sources & evidence

ORD record
ord-fced61c631e9440199e0996356f6e01b
Source dataset
uspto-grants-1991_07
Patent number
US05030715

Reaction notes

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