Methyl 2-chloro-1,3-thiazole-5-carboxylate → methyl 7-methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylate

HRID 1086608Notes

Reaction equation

HRID 1086608 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:7]([C:8]([NH2:10])=[O:9])[C:6]([NH2:12])=[CH:5][CH:4]=1.Cl[C:14]1[S:15][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:17]N=1>>[CH3:1][O:2][C:3]1[CH:11]=[C:7]2[C:6](=[CH:5][CH:4]=1)[N:12]=[C:14]1[S:15][C:16]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][N:10]1[C:8]2=[O:9]

Participants

3

Reactant 2

HCID 12897294Methyl 2-chloro-1,3-thiazole-5-carboxylateHCID 203382172-Amino-5-methoxybenzamide

Product 1

HCID 15569301methyl 7-methoxy-5-oxo-5H-thiazolo[2,3-b]quinazoline-2-carboxylate

Procedure

16.5 g of 5-methoxyanthranilamide and 18.64 g of methyl 2-chlorothiazole-5-carboxylate were stirred for 11/2 hours at 160° C. After working up in the conventional manner 24.7 g (85%) of the above compound was obtained; m.p. 187°-192° C.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-c8cd4fc5b6ef4aa5827a0137b1cd9e82
Source dataset
uspto-grants-1991_07
Patent number
US05030727

Reaction notes

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