2-Amino-6-chlorobenzamide → 2-methyl-6-chloro-5H-thiazolo-(2,3-b)-quinazolin-5-one

HRID 1086609Notes

Reaction equation

HRID 1086609 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:11])[C:7]=1[C:8]([NH2:10])=[O:9].Br[C:13]1[S:14][C:15]([CH3:18])=[CH:16]N=1>>[CH3:18][C:15]1[S:14][C:13]2=[N:11][C:6]3[C:7]([C:8](=[O:9])[N:10]2[CH:16]=1)=[C:2]([Cl:1])[CH:3]=[CH:4][CH:5]=3

Participants

3

Reactant 2

HCID 136759682-Amino-6-chlorobenzamideHCID 219061062-Bromo-5-methyl-1,3-thiazole

Product 1

HCID 198263422-methyl-6-chloro-5H-thiazolo-(2,3-b)-quinazolin-5-oneYield 78.1%

Procedure

10.2 g of 6-chloroanthranilamide and 10.74 g of 2-bromo-5-methylthiazole were stirred at 140° C. for 2 hours. After working up in the conventional manner there was obtained 11.7 g (78%) of the above compound; m.p. 235°-236° C.

Sources & evidence

ORD record
ord-cc7be1eb2d764f198dbfe2b4c532da35
Source dataset
uspto-grants-1991_07
Patent number
US05030727

Reaction notes

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