2-Chlorothiazole → 9-fluoro-5H-thiazolo-(2,3-b)-quinazolin-5-one

HRID 1086612Notes

Reaction equation

HRID 1086612 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]([C:5]([NH2:7])=[O:6])[C:3]=1[NH2:11].Cl[C:13]1[S:14][CH:15]=[CH:16]N=1>>[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:4]2[C:3]=1[N:11]=[C:13]1[S:14][CH:15]=[CH:16][N:7]1[C:5]2=[O:6]

Participants

3

Reactant 2

HCID 764292-ChlorothiazoleHCID 152567912-Amino-3-fluorobenzamide

Product 1

HCID 132170349-fluoro-5H-thiazolo-(2,3-b)-quinazolin-5-oneYield 79%

Procedure

15.4 g of 3-fluoroanthranilamide and 13.1 g of 2-chlorothiazole were stirred for 7 hours at 150° C. After working up in the conventional manner there was obtained 17.3 g (79%) of the above compound; m.p. 187°-189° C.

Sources & evidence

ORD record
ord-31aa38c7c1994a8a9269c5d5ac9a8908
Source dataset
uspto-grants-1991_07
Patent number
US05030727

Reaction notes

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