2-Amino-6-fluorobenzamide → 2-methyl-6-fluoro-5H-thiazolo-(2,3-b)-quinazolin-5-one

HRID 1086614Notes

Reaction equation

HRID 1086614 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([NH2:11])[C:7]=1[C:8]([NH2:10])=[O:9].Cl[C:13]1[S:14][C:15]([CH3:18])=[CH:16]N=1>>[CH3:18][C:15]1[S:14][C:13]2=[N:11][C:6]3[C:7]([C:8](=[O:9])[N:10]2[CH:16]=1)=[C:2]([F:1])[CH:3]=[CH:4][CH:5]=3

Participants

3

Reactant 2

HCID 27789392-Amino-6-fluorobenzamideHCID 109970832-Chloro-5-methyl-1,3-thiazole

Product 1

HCID 141004402-methyl-6-fluoro-5H-thiazolo-(2,3-b)-quinazolin-5-oneYield 83%

Procedure

10.8 g of 6-fluoroanthanilamide and 9.4 g of 2-chloro-5-methylthiazole were stirred for 7 hours at 150° C. After working up in the conventional manner there was obtained 13.5 g (83%) of the above compound; m.p. 245°-246° C.

Sources & evidence

ORD record
ord-1c97d44639d9428ea5415169bbf5b50a
Source dataset
uspto-grants-1991_07
Patent number
US05030727

Reaction notes

Loading…