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HRID1086803

反应详情

EQUATION

反应方程式

HRID 1086803 的结构方程式

REACTANTS

反应物

2
结构：Cc1nc(Cl)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
HCID54278501

未命名化合物

结构：Cl.N[C@H]1CC[C@H](O)CC1
HCID178479278

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nc(N[C@H]2CC[C@H](O)CC2)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1
HCID178433181

未命名化合物

收率 79.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

A mixture of 6-chloro-2-methyl-9-(β-D-ribofuranosyl)-9H-purine (902 mg), trans-4-aminocyclohexanol hydrochloride (1.14 g) and DEA (1.94 g) in isopropanol (50 ml) was heated at reflux with stirring under nitrogen for 17 h. The resulting cooled reaction mixture was adsorbed onto silica (Merck 9385) and purified by column chromatography on silica (Merck 9385) eluting with System B (10:1 then 8:1) to give the title compound (0.9 g) as a solid.

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureat reflux
  3. temperatureThe resulting cooled
  4. customreaction mixture
  5. custompurified by column chromatography on silica (Merck 9385)
  6. washeluting with System B (10:1