HCID 54514761, compound → HCID 178456463, compound

HRID 1086828Notes

Reaction equation

HRID 1086828 reaction equation
[C:1]([NH:4][CH:5]1[N:10]=[N:9][C:8]2[N:11]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:12](=[O:19])[N:13]([CH2:16][CH2:17][CH3:18])[C:14](=[O:15])[C:7]=2S1)(=[O:3])[CH3:2]>O1CCOCC1>[C:1]([NH:4][C:5]1[C:7]2[C:14](=[O:15])[N:13]([CH2:16][CH2:17][CH3:18])[C:12](=[O:19])[N:11]([CH2:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[C:8]=2[NH:9][N:10]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 54514761HCID 54514761, compound

Product 1

HCID 178456463HCID 178456463, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 3-acetylamino-8-benzyl-6-propylpyrimido[4,5-e][1,3,4]thiadiazine-5,7(6H,8H)dione (4.0 g) in dioxane (50 ml) was refluxed for one hour. The reaction mixture was concentrated to dryness, and the concentrate was dissolved in methanol. Insoluble sulfur was filtered off. To the filtrate was added a small volume of water, which was left standing for cooling, then colorless crystals (3.4 g), m.p. 108°-110° C., were obtained.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness
  2. dissolutionthe concentrate was dissolved in methanol
  3. filtrationInsoluble sulfur was filtered off
  4. additionTo the filtrate was added a small volume of water, which
  5. waitwas left
  6. temperaturefor cooling

Sources & evidence

ORD record
ord-811e04a76813473b967352a3343985ae
Source dataset
uspto-grants-1991_07
Patent number
US05032594

Reaction notes

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