HCID 14986831, compound → HCID 178456463, compound

HRID 1086829Notes

Reaction equation

HRID 1086829 reaction equation
[C:1]([NH:4][C:5](=S)[NH:6][NH:7][C:8]1[N:13]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:12](=[O:21])[N:11]([CH2:22][CH2:23][CH3:24])[C:10](=[O:25])[CH:9]=1)(=[O:3])[CH3:2]>CN(C)C=O>[C:1]([NH:4][C:5]1[C:9]2[C:10](=[O:25])[N:11]([CH2:22][CH2:23][CH3:24])[C:12](=[O:21])[N:13]([CH2:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:8]=2[NH:7][N:6]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 14986831HCID 14986831, compound

Product 1

HCID 178456463HCID 178456463, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 6-(4-acetylthiosemicarbazido)-1-benzyl-3-propylpyrimidine-2,4(1H,3H)-dione (3.0 g) in dimethylformamide (50 ml) was heated at 100° to 110° C. for 60 hours. The reaction mixture was concentrated and dissolved in 90% methanol. The solution was left standing for cooling to give pale brown crystals, followed by recrystallization from ethanol to obtain colorless crystals, m.p. 108° to 110° C.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. dissolutiondissolved in 90% methanol
  3. waitThe solution was left
  4. temperaturefor cooling
  5. customto give pale brown crystals
  6. customfollowed by recrystallization from ethanol
  7. customto obtain colorless crystals, m.p. 108° to 110° C.

Sources & evidence

ORD record
ord-e303c1a0649a443cb2fe440c7e0399a4
Source dataset
uspto-grants-1991_07
Patent number
US05032594

Reaction notes

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