Sodium hydride → HCID 135778496, compound

HRID 1086832Notes

Reaction equation

HRID 1086832 reaction equation
[H-].[Na+].[NH2:3][C:4]1[N:5]([CH2:25][CH2:26]Cl)[N:6]=[C:7]2[C:12]=1[C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH3:16])[C:9](=[O:17])[N:8]2[CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:18]([N:8]1[C:7]2=[N:6][N:5]3[CH2:25][CH2:26][NH:3][C:4]3=[C:12]2[C:11](=[O:13])[N:10]([CH2:14][CH2:15][CH3:16])[C:9]1=[O:17])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 24758Sodium hydrideHCID 14986848HCID 14986848, compound

Product 1

HCID 135778496HCID 135778496, compound

Procedure

Sodium hydride (60% oil, 0.8 g) was added in portions to a stirring solution of 3-amino-7-benzyl-2-(2-chloroethyl) -5-propyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (4.9 g) under cooling with ice bath. The mixture was stirred for 17 hours and was concentrated to dryness. The residue was triturated with water and the resulting crystals were collected by filtration, washed with water and dried.

Workup

  1. temperatureunder cooling with ice bath
  2. concentrationwas concentrated to dryness
  3. customThe residue was triturated with water
  4. filtrationthe resulting crystals were collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-c71be86405b247b8bea07e491fdc362e
Source dataset
uspto-grants-1991_07
Patent number
US05032594

Reaction notes

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