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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1086856Generated: November 2, 2026

1H-Indole-5-Carboxylic Acid → 1-(Indole-5-carbonyl)-4-[2-(4-nitrophenyl)ethyl]piperazine

https://huagongshe.com/reaction/1086856

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1H-Indole-5-Carboxylic AcidHCID 74280—
Reactant1-[2-(4-Nitrophenyl)ethyl]piperazineHCID 14985965—
Product1-(Indole-5-carbonyl)-4-[2-(4-nitrophenyl)ethyl]piperazineHCID 14986000—

Reaction Steps

In the manner described in Example 24, indole-5-carboxylic acid (100 mg, 0.62 mmol) and 1-[2-(4-nitrophenyl)ethyl]piperazine (151 mg, 0.64 mmol) gave, after purification by flash column chromatography on silica gel, eluting with CH2Cl2 /MeOH/NH3 ; 95:5:0.5 and trituration with hexane/EtOAc, the piperazine (38 mg, 16%), mp 204°-206° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05032598
Source datasetuspto-grants-1991_07
ORD IDord-250d25133e02467090b1826a23fbd0cf
Source noteuspto-grants-1991_07