Sodium Methoxide → HCID 15752838, compound

HRID 1086870Notes

Reaction equation

HRID 1086870 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH:15]([CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])[C:14](=[O:23])[O:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+]>CO>[CH2:1]([O:8][C:9]([NH:11][CH:15]([C:14]([O:13][CH3:12])=[O:23])[CH2:16][CH2:17][CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 15752834HCID 15752834, compound

Product 1

HCID 15752838HCID 15752838, compoundYield 79.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.20 g (0.62 mmol) of the resultant compound of Example 187 in methanol was treated with sodium methoxide and stirred at ambient temperature for 2 h. The solvent was removed in vacuo, and the residue was acidified with IN HCl, extracted with chloroform, and concentrated to give 159 mg of the desired compound.

Workup

  1. customThe solvent was removed in vacuo
  2. extractionextracted with chloroform
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-e502e3ebf2754cdb97b228c8e5aeba8e
Source dataset
uspto-grants-1991_07
Patent number
US05032577

Reaction notes

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