HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 1-methyl-1H-indol-6-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Cyclohexane | HCID 8078 | — |
| Reactant | 6-(Benzyloxy)-1-methyl-1H-indole | HCID 12348384 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Diisopropyl Ether | HCID 7914 | — |
| Product | 1-methyl-1H-indol-6-ol | HCID 12203496 | — |
Reaction Steps
The mixture constituted by 0.24 mole (57 g) 6-benzyloxy-1-methylindole, 5.7 g 10% palladium-on-charcoal, 114 ml cyclohexane and 170 ml 96° ethanol is heated for 30 minutes under reflux. It is filtered hot in order to remove the catalyst. After evaporation of the filtrate under vacuum, an oil is obtained which, when dissolved in isopropyl ether, leads after evaporation to dryness to the desired product. It melts at 74° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05034015 |
| Source dataset | uspto-grants-1991_07 |
| ORD ID | ord-84f3212edfae4471b1c61c4278551ffb |
| Source note | uspto-grants-1991_07 |