反应详情

A mixture consisting of 1.86 g (0.011 mole) of 4-chloropyrido-[2,3-d]pyrimidine, 2.0 g (0.011 mole) of 2-[4-(t-butyl)phenyl]ethanol, and 40 mL of toluene containing a little HCl gas was stirred at room temperature. The mixture was then cooled, and a yellow solid was collected. This was washed with hexane, then partitioned between 1N NaOH and CH2Cl2. The CH2Cl2 layer was dried over MgSO4, then the solvent was removed under vacuum to leave a yellow solid, which was recrystallized from hexane. Yield 2.5 g. M.P. 77-79° C.

1. temperatureThe mixture was then cooled
2. customa yellow solid was collected
3. washThis was washed with hexane
4. custompartitioned between 1N NaOH and CH2Cl2
5. dry with materialThe CH2Cl2 layer was dried over MgSO4
6. customthe solvent was removed under vacuum
7. customto leave a yellow solid, which
8. customwas recrystallized from hexane