HCID 14330456, compound → 5-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

HRID 1087007Notes

Reaction equation

HRID 1087007 reaction equation
C(OC([NH:8][CH:9]1[CH2:14][C:13]2[C:15]([O:19][CH3:20])=[CH:16][CH:17]=[CH:18][C:12]=2[S:11][CH2:10]1)=O)(C)(C)C>FC(F)(F)C(O)=O>[CH3:20][O:19][C:15]1[C:13]2[CH2:14][CH:9]([NH2:8])[CH2:10][S:11][C:12]=2[CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 1

HCID 14330456HCID 14330456, compound

Product 1

HCID 143304585-Methoxy-3,4-dihydro-2H-1-benzothiopyran-3-amine

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 10 g of N-t-butoxycarbonyl-3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine in 30 ml of trifluoroacetic acid is kept at room temperature for 1 hour. The solvent is removed in vacuo, the residue is treated with 1 N NaOH and the product is extracted with ether. After drying over magnesium sulfate, the solvent is removed in vacuo to afford 3,4-dihydro-5-methoxy-2H-[1]-benzothiopyran-3-amine as an oil.

Workup

  1. customThe solvent is removed in vacuo
  2. additionthe residue is treated with 1 N NaOH
  3. extractionthe product is extracted with ether
  4. dry with materialAfter drying over magnesium sulfate
  5. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-a5b13301d0994f3f8b5aa53e09ba0aef
Source dataset
uspto-grants-1991_07
Patent number
US05034381

Reaction notes

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