反应详情

A mixture of 2(4-bromo-2-thienyl)-ethylamine (37 g) and phthalic anhydride (26.7 g) in glacial acetic acid (500 ml) is heated at reflux over 15 hours. It is concentrated at reduced pressure, the residue is triturated with ethanol and collected. The solid is recrystallized from ethanol to afford N-[2-(4-bromo-2-thienyl)ethyl]-phthalimide, m.p. 115°-117°.

1. temperatureis heated
2. temperatureat reflux over 15 hours
3. concentrationIt is concentrated at reduced pressure
4. customthe residue is triturated with ethanol
5. customcollected
6. customThe solid is recrystallized from ethanol