反应详情

1.5 g of 4-[2-(ethylamino)-1-hydroxyethyl]-benzonitrile, 2.1 g of potassiumcarbonate, 1.7 g of 1-bromo-3-(propylthio)-propane was mixed in 50 ml acetonitrile and refluxed over night. The mixture was filtered and evaporated and the residue was dissolved in 2 M hydrochloric acid. The acidic waterlayer was washed twice with ether, alkalized with 10 M sodiumhydroxide and extracted with three portions of dichloromethane.

1. temperaturerefluxed over night
2. filtrationThe mixture was filtered
3. customevaporated
4. dissolutionthe residue was dissolved in 2 M hydrochloric acid
5. washThe acidic waterlayer was washed twice with ether
6. extractionextracted with three portions of dichloromethane