反应详情

18.6 Grams of 5-acetyl-2,2-dimethyl-1,3-dioxane-4,6-dione and 50 ml tetrahydrofuran solution containing 22.2 g of 4-(1-ethoxyethoxy)cinnamyl alcohol were refluxed for 6 hours. After the reaction was completed, the solvent was removed by evaporation, and the residue thus obtained was purified by means of a silica gel column chromatography (eluent: ethyl acetate:n-hexane=1:4) to yield 5.8 g of 4-[(1-ethoxy)ethoxy]cinnamyl acetoacetate as in the form of an oily substance.

1. temperaturewere refluxed for 6 hours
2. customthe solvent was removed by evaporation
3. customthe residue thus obtained
4. customwas purified by means of a silica gel column chromatography (eluent: ethyl acetate:n-hexane=1:4)