反应详情

A solution of 3-(2,4-difluorophenylthio)-4-nitrobenzoic acid (1.2 g) in 20% hydrogen chloride in ethanol (3 ml) was refluxed for 2 hours. The mixture was concentrated. The residue was dissolved in ethyl acetate and washed with an aqueous solution of sodium bicarbonate and water successively. The extract was evaporated and the residual oil was crystallized from a mixture of hexane and ethanol to give crystals of ethyl 3-(2,4-difluorophenylthio)-4-nitrobenzoate (1.1 g).

1. concentrationThe mixture was concentrated
2. dissolutionThe residue was dissolved in ethyl acetate
3. washwashed with an aqueous solution of sodium bicarbonate and water successively
4. customThe extract was evaporated
5. customthe residual oil was crystallized from a mixture of hexane and ethanol